I.R.A. Istituto Ricerche Applicate designs and manufactures class III injectable medical devices for orthopaedic purposes (linear and crosslinked hyaluronic acid), whose strength lies in its high purity, low concentration of nucleic acids and proteins and whose levels of endotoxins is much lower than that required by the European Pharmacopeia for injectable products (below 0.5 EU/ml). The extremely sophisticated crosslinking and purification process ensures levels of residual crosslinking agents compliant with the analytical determination limits. These factors minimise any hypersensitivity reactions, making our medical devices extremely safe. The availability of different concentrations allows us to customise the treatment according to the requirements of each patient.